If his wife is living, she will have spousal rights to his probate estate.  Also, under Florida law, he would be unable to transfer homestead property to anyone other than a spouse under his will.  The first thing he should do is ascertain whether or not she is alive.  He can hire companies that track down heirs.  If she is still alive, she would have to be notified upon filing for probate, so it is best to address the issue now.